The Factors Affecting Tumour Oxygenation

Factors Affecting Tissue Oxygenation in Erythrocyte Transfusions.

Red blood cell transfusions are used to increase the oxygen-carrying capacity of blood in anemic states. But, because of the changes during storage of blood components and the specifics of preparation, erythrocytes may have controversial effects on tissue oxygenation and microcirculation. Also, the patient situation may play a role in the differing responses in oxygenation and microcirculation....

Head and Neck Cancer − Factors Affecting Tumour Growth

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Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters.

Near-infrared spectroscopy (NIRS) can be used to noninvasively measure changes in the concentrations of oxy- and deoxyhemoglobin in tissue. We have previously shown that while global changes can be reliably measured, focal changes can produce erroneous estimates of concentration changes (NeuroImage 13 (2001), 76). Here, we describe four separate sources for systematic error in the calculation o...

Ewing's tumour affecting the medial cuneiform bone.

ΔR2* as Biomarkers of Tumour Oxygenation

Introduction: Tumour hypoxia is associated with aggressive, malignant phenotypes and is a major determinant of treatment response and patient outcome. A range of imaging methods are being investigated that may provide a means of assessing tumour hypoxia in vivo [1]. Molecular oxygen is paramagnetic, and therefore in solution shortens the MR longitudinal relaxation time T1 of surrounding water p...